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crotonate fermentation (to acetate and cyclohexane carboxylate)

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
3-hydroxypimeloyl-CoA + NAD+ <=> H+ + NADH + 3-oxopimeloyl-CoA 1.1.1.259 3-hydroxypimeloyl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase


(S)-3-hydroxybutyryl-CoA <=> H2O + crotonyl-CoA 1.3.8.7 medium-chain acyl-CoA dehydrogenase
4.2.1.116 3-hydroxypropionyl-CoA dehydratase
4.2.1.150 short-chain-enoyl-CoA hydratase
4.2.1.17 enoyl-CoA hydratase




2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O <=> 3-hydroxypimeloyl-CoA + H+ 3.7.1.21 6-oxocyclohex-1-ene-1-carbonyl-CoA hydratase

cyclohexanecarboxyl-CoA + oxidized_electron_transfer_flavoprotein + H+ <=> cyclohex-1-ene-1-carbonyl-CoA + reduced_flavodoxin 1.3.8.11 cyclohexane-1-carbonyl-CoA dehydrogenase (electron-transfer flavoprotein)

6-hydroxycyclohex-1-ene-1-carbonyl-CoA <=> cyclohexa-1,5-diene-1-carbonyl-CoA + H2O 4.2.1.100 cyclohexa-1,5-dienecarbonyl-CoA hydratase

acetyl-CoA + crotonate <=> acetate + crotonyl-CoA 2.8.3
2.8.3.1 propionate CoA-transferase
2.8.3.12 glutaconate CoA-transferase
2.8.3.9 butyrate---acetoacetate CoA-transferase




glutaryl-CoA + oxidized_electron_transfer_flavoprotein + H+ <=> glutaconyl-CoA + reduced_flavodoxin not assigned

3-oxopimeloyl-CoA + CoA <=> glutaryl-CoA + acetyl-CoA 2.3.1
2.3.1.16 acetyl-CoA C-acyltransferase


cyclohexanecarboxyl-CoA + H2O <=> cyclohexanecarboxylate + CoA + H+ 3.1.2

6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD+ <=> H+ + 6-oxocyclohex-1-ene-1-carbonyl-CoA + NADH 1.1.1.368 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase

6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O <=> 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA 3.7.1.21 6-oxocyclohex-1-ene-1-carbonyl-CoA hydratase

cyclohex-1-ene-1-carbonyl-CoA + oxidized_electron_transfer_flavoprotein + H+ <=> cyclohexa-1,5-diene-1-carbonyl-CoA + reduced_flavodoxin 1.3.8.10 cyclohex-1-ene-1-carbonyl-CoA dehydrogenase

(S)-3-hydroxybutyryl-CoA + NAD+ <=> acetoacetyl-CoA + NADH + H+ 1.1.1.178 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase
1.1.1.36 acetoacetyl-CoA reductase



glutaconyl-CoA + H+ <=> CO2 + crotonyl-CoA 1.3.8.6 glutaryl-CoA dehydrogenase (ETF)
6.4.1.4 methylcrotonoyl-CoA carboxylase
7.2.4.5 glutaconyl-CoA decarboxylase



acetyl-CoA <=> acetoacetyl-CoA + CoA 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH)
2.3.1.155 acetyl-CoA C-myristoyltransferase
2.3.1.16 acetyl-CoA C-acyltransferase
2.3.1.38 [acyl-carrier-protein] S-acetyltransferase
2.3.1.9 acetyl-CoA C-acetyltransferase





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